Open AccessGlut-1 as a prognostic biomarker in oral squamous cell carcinoma
Author(s) -
Jyotsna M Harshani,
Sivaranjani Yeluri,
Venkateswara Rao Guttikonda
Publication year - 2014
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.151318
Subject(s) - immunohistochemistry , immunostaining , medicine , basal cell , pathology , staining , biomarker , biology , biochemistry
Glut-1 is a glucose transporter protein, the expression of which is upregulated in malignant cells which show increased glucose uptake. Alterations in expression of Glut-1 have been reported in several pre-malignant and malignant lesions. The objectives of the present study were to compare the expression of Glut-1 in normal persons and in patients with oral squamous cell carcinoma (OSCC), to correlate the expression of Glut-1 with respect to clinical staging of OSCC and to evaluate the expression of Glut-1 with respect to different histopathological grades of OSCC.