Open AccessImmunohistochemical characterization of cyclin dependent kinase-4 in different histological grades of oral leukoplakia and oral squamous cell carcinoma
Author(s) -
Ndvn Shyam,
Nirmala N Rao,
Ramandeep Singh Narang,
Jiji George,
Sanjay Reddy Bommu,
Kiran Grover
Publication year - 2014
Publication title -
journal of oral and maxillofacial pathology/journal of oral and maxillofacial pathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.455
H-Index - 25
eISSN - 1998-393X
pISSN - 0973-029X
DOI - 10.4103/0973-029x.131896
Subject(s) - staining , immunohistochemistry , pathology , biology , cytoplasm , cell cycle , carcinoma , cell , medicine , microbiology and biotechnology , genetics
Cyclin dependent kinase-4 (CDK4) encoded by CDK gene, is a heterodimer protein of cell cycle in G1-S transition. This study aimed to characterize the CDK4 immunoreactivity in different histological grades of oral leukoplakias (OLs) and oral squamous cell carcinomas (OSCCs) and also aims to discuss its probable role in the tumor biogenesis.