Open AccessVariant of plasmablastic microlymphoma in Castleman disease: a case report and review of the literature
Author(s) -
Nathan Artom,
Marcello Brig,
Luca Paris,
Anna Lisa Garlaschelli,
Marina Cavalière,
Gian Luca Michelis,
Claudia Venturino,
Silvia Marina Ardoino,
Ezio Venturino,
Paola Gnerre,
Rodolfo Tassara
Publication year - 2018
Publication title -
italian journal of medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.134
H-Index - 10
eISSN - 1877-9352
pISSN - 1877-9344
DOI - 10.4081/itjm.2018.1063
Subject(s) - medicine , castleman disease , pathology , lymph node , plasmablastic lymphoma , lymphoid hyperplasia , sarcoma , lymph , anemia , disease , lymphoma
Castleman disease (CD) is a rare lymphoproliferative disorder also known as angiofollicular lymph node hyperplasia or giant lymph node hyperplasia. CD can be unicentric CD (UCD) or multicentric CD (MCD). MCD affects more than one group of lymph nodes and/or lymphoid tissues and it is frequently associated with HIV and human herpes virus 8 (HHV-8) infections and, in contrast with UCD, it often results in systemic symptoms, such as fever, fatigue, anemia, inflammatory syndrome. HHV- 8-associated MCD recognizes HHV-8 as an etiopathogenetic agent and occurs generally in HIV-positive subjects. Our report describes an HHV-8 positive Castleman disease with plasmablastic microlymphoma occurring in a 51-year-old HIV seronegative woman, with a previous history of HBV infection and Kaposi’s sarcoma, who presented elevated procalcitonin levels during the acute phase of CD.