Koilocytes are enriched for alkaline-labile sites | Zendy

Elva I. CortésGutiérrez | Zendy; Martha I. DávilaRodríguez | Zendy; José Luís Fernández | Zendy; Carmen LópezFernández | Zendy; Jaime Gosálvez | Zendy

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Koilocytes are enriched for alkaline-labile sites

Author(s) -

Elva I. CortésGutiérrez,

Martha I. DávilaRodríguez,

José Luís Fernández,

Carmen LópezFernández,

Jaime Gosálvez

Publication year - 2010

Publication title -

european journal of histochemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.754

H-Index - 42

eISSN - 2038-8306

pISSN - 1121-760X

DOI - 10.4081/ejh.2010.e32

Subject(s) - koilocyte , fluorescence in situ hybridization , chromatin , dna , genome , biology , microbiology and biotechnology , chemistry , genetics , gene , cervical intraepithelial neoplasia , cancer , cervical cancer , chromosome

This study investigated possible variations in the chromatin structure of koilocytes resulting from human papillomavirus (HPV) infection. Alkaline-labile sites (ALS) were detected with the DNA breakage detection–fluorescence in situ hybridization (DBD-FISH) technique using a whole human genome DNA probe obtained from individuals without koilocytosis. The variable levels of ALS present were measured quantitatively using image analysis after whole-genome DNA hybridization. A significant increase in the number of ALS was observed in koilocytes compared with normal cells. We demonstrated that the presence of ALS could be an indicator of chromatin change in koilocytes caused by HPV infection

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