Anti-hepatitis C Virus Activity of Novel β-D-2′-C-methyl-4′-azido Pyrimidine Nucleoside Phosphoramidate Prodrugs | Zendy

Ramu Rondla | Zendy; Steven J. Coats | Zendy; Tamara R. McBrayer | Zendy; Jason Grier | Zendy; Melissa Johns | Zendy; Phillip M. Tharnish | Zendy; Tony Whitaker | Zendy; Longhu Zhou | Zendy; Raymond F. Schinazi | Zendy

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Anti-hepatitis C Virus Activity of Novel β-D-2′-C-methyl-4′-azido Pyrimidine Nucleoside Phosphoramidate Prodrugs

Author(s) -

Ramu Rondla,

Steven J. Coats,

Tamara R. McBrayer,

Jason Grier,

Melissa Johns,

Phillip M. Tharnish,

Tony Whitaker,

Longhu Zhou,

Raymond F. Schinazi

Publication year - 2009

Publication title -

antiviral chemistry and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.919

H-Index - 51

eISSN - 2040-2066

pISSN - 0956-3202

DOI - 10.3851/imp1400

Subject(s) - phosphoramidate , cytidine , prodrug , nucleoside , uridine , chemistry , pyrimidine , ns5b , hepatitis c virus , stereochemistry , biochemistry , biology , rna , enzyme , virus , virology , hepacivirus , gene

2'-C-methyl and 4'-azido nucleosides have previously demonstrated inhibition of hepatitis C virus (HCV) replication by targeting the RNA-dependent RNA polymerase NS5B. In an effort to discover new and more potent anti-HCV agents, we envisioned synthesizing nucleoside analogues by combining the 2'-C-methyl-moiety with the 4'-azido-moiety into one molecule.

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