A NEW RP-UPLC METHOD FOR SIMULTANEOUS QUANTIFICATION OF IVABRADINE AND METOPROLOL IN COMBINED DOSAGE FORMS | Zendy

R Hemalatha | Zendy; B Venkatesh | Zendy

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A NEW RP-UPLC METHOD FOR SIMULTANEOUS QUANTIFICATION OF IVABRADINE AND METOPROLOL IN COMBINED DOSAGE FORMS

Author(s) -

R Hemalatha,

B Venkatesh

Publication year - 2022

Publication title -

ymer digital

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.103

H-Index - 5

ISSN - 0044-0477

DOI - 10.37896/ymer21.04/35

Subject(s) - ivabradine , metoprolol , chromatography , high performance liquid chromatography , chemistry , volumetric flow rate , materials science , heart rate , medicine , thermodynamics , blood pressure , physics

An accurate and yet fast, easy-to-use, affordable, sensitive, single method for measuring Ivabradine and Metoprolol in bulk and pharmaceutical products using Reversed-Phase Ultra-Performance Liquid Chromatography (RP-UPLC) was developed. A Hibar C18 column was used with a running phase composed of Water: ACN (60:40 v/v) at a flow rate of 0.5 ml/min. UV detection was used at a wavelength of 260 nm. The correlation parameters for Ivabradine and Metoprolol were found to be of the order of 99.9% and % MSD <2. The validation results agreed with what's acceptable and had good limits. This method, proposed as a regular analysis and quality control tool for medications that contain these active drugs either individually or in combination, was evident to be a suitable one

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