Open AccessA NEW RP-UPLC METHOD FOR SIMULTANEOUS QUANTIFICATION OF IVABRADINE AND METOPROLOL IN COMBINED DOSAGE FORMS
Author(s) -
R Hemalatha,
B Venkatesh
Publication year - 2022
Publication title -
ymer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.103
H-Index - 5
ISSN - 0044-0477
DOI - 10.37896/ymer21.04/35
Subject(s) - ivabradine , metoprolol , chromatography , high performance liquid chromatography , volumetric flow rate , chemistry , materials science , heart rate , medicine , blood pressure , thermodynamics , physics
An accurate and yet fast, easy-to-use, affordable, sensitive, single method for measuring Ivabradine and Metoprolol in bulk and pharmaceutical products using Reversed-Phase Ultra-Performance Liquid Chromatography (RP-UPLC) was developed. A Hibar C18 column was used with a running phase composed of Water: ACN (60:40 v/v) at a flow rate of 0.5 ml/min. UV detection was used at a wavelength of 260 nm. The correlation parameters for Ivabradine and Metoprolol were found to be of the order of 99.9% and % MSD <2. The validation results agreed with what's acceptable and had good limits. This method, proposed as a regular analysis and quality control tool for medications that contain these active drugs either individually or in combination, was evident to be a suitable one