Open AccessDiabetes and pancreatic cancer: Exploring the two-way traffic
Author(s) -
Ayan Roy,
Jayaprakash Sahoo,
Sadishkumar Kamalanathan,
Dukhabandhu Naik,
Pazhanivel Mohan,
Raja Kalayarasan
Publication year - 2021
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v27.i30.4939
Subject(s) - diabetes mellitus , medicine , pancreatic cancer , population , bioinformatics , pathogenesis , cancer , oncology , risk factor , intensive care medicine , endocrinology , biology , environmental health
Pancreatic cancer (PC) is often associated with a poor prognosis. Long-standing diabetes mellitus is considered as an important risk factor for its development. This risk can be modified by the use of certain antidiabetic medications. On the other hand, new-onset diabetes can signal towards an underlying PC in the elderly population. Recently, several attempts have been made to develop an effective clinical tool for PC screening using a combination of history of new-onset diabetes and several other clinical and biochemical markers. On the contrary, diabetes affects the survival after treatment for PC. We describe this intimate and complex two-way relationship of diabetes and PC in this review by exploring the underlying pathogenesis.