Open Access(-)-Epigallocatechin-3-gallate inhibits VEGF expression induced by IL-6 бvia Stat3 in gastric cancer
Author(s) -
Bin Zhu,
Huayun Chen,
Wei Zhan,
Chengyou Wang,
Shirong Cai,
Zhao Wang,
Changhua Zhang,
Yulong He
Publication year - 2011
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v17.i18.2315
Subject(s) - angiogenesis , vascular endothelial growth factor , matrigel , microbiology and biotechnology , stat3 , blot , chemistry , biology , cancer research , signal transduction , biochemistry , vegf receptors , gene
To demonstrate that (-)-Epigallocatechin-3-gallate (EGCG) inhibits vascular endothelial growth factor (VEGF) expression and angiogenesis induced by interleukin-6 (IL-6) via suppressing signal transducer and activator of transcription 3 (Stat3) activity in gastric cancer.