Open AccessInterferon-α induced severe thrombocytopenia: A case report and review of the literature
Author(s) -
Li Li,
Dong Han,
Jun Lu
Publication year - 2010
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v16.i11.1414
Subject(s) - medicine , discontinuation , alpha interferon , immune thrombocytopenia , pegylated interferon , immunology , interferon , interferon alfa , alpha (finance) , virus , hepatitis c virus , gastroenterology , ribavirin , platelet , surgery , construct validity , patient satisfaction
We report a case of severe thrombocytopenia following pegylated interferon-alpha 2a (Peg-IFN-alpha 2a) treatment of hepatitis C virus infection and summarize the clinical characteristics of 16 cases of IFN-alpha induced severe thrombocytopenia and its immune-mediated mechanism. Discontinuation of IFN-alpha and early administration of immunosuppressants are the effective therapy for IFN-alpha induced severe thrombocytopenia.