Open AccessHeterogeneity in predisposition of hepatic cells to be induced into pancreatic endocrine cells by PDX-1
Author(s) -
Shun Lu,
Weiping Wang,
Xiaofei Wang,
Zongmei Zheng,
Ping Chen,
Kangtao Ma,
Chen Zhou
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i15.2277
Subject(s) - transfection , enteroendocrine cell , cell culture , biology , medicine , endocrinology , beta cell , ectopic expression , cancer research , cell , microbiology and biotechnology , insulin , islet , endocrine system , hormone , genetics
The role of Pancreatic and Duodenal Homeobox-1 (PDX-1) as a major regulator of pancreatic development determines the function and phenotype of beta cell. In this study, potential plasticity of liver cells into pancreatic endocrine cells induced by PDX-1 was evaluated.