Open AccessIdentification of the immunogenic domains in HBsAg preS1 region using overlapping preS1 fragment fusion proteins
Author(s) -
Weiguo Hu,
Jun Wei,
Hengchuan Xia,
Xin-Xiu Yang,
Feng Li,
Guangdi Li,
Yuan Wang,
Zu-Chuan Zhang
Publication year - 2005
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v11.i14.2088
Subject(s) - immunogenicity , epitope , hbsag , fusion protein , hepatitis b virus , neutralizing antibody , immune system , virology , antibody , microbiology and biotechnology , chemistry , virus , recombinant dna , biology , immunology , gene , biochemistry
The incorporation of hepatitis B virus (HBV) preS1 region into epitope-based vaccines against HBV has been accepted widely, but the incorporate site and size of preS1 sequence is controversial. Therefore our purpose was to further investigate its immunogenic domains for the epitope-based hepatitis B vaccine design.