Open AccessEnhanced expressions and activations of leukotriene C4 synthesis enzymes in D-galactosamine/lipopolysaccharideinduced rat fulminant hepatic failure model
Author(s) -
Kuifen Ma,
Hongyu Yang,
Zhe Chen,
Luo-yang Qi,
Danyan Zhu,
Yijia Lou
Publication year - 2008
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.14.2748
Subject(s) - leukotriene c4 , fulminant hepatic failure , glutathione , enzyme , western blot , argininosuccinate synthase , leukotriene , galactosamine , liver injury , chemistry , eicosanoid metabolism , enzyme assay , biochemistry , glucuronosyltransferase , eicosanoid , medicine , microbiology and biotechnology , endocrinology , biology , microsome , arachidonic acid , amino acid , gene , arginase , arginine , glucosamine , liver transplantation , asthma , transplantation
To investigate the expression and activity of leukotriene C4 (LTC4) synthesis enzymes and their underlying relationship with cysteinyl leukotriene (cys-LT) generation in a rat fulminant hepatic failure (FHF) model induced by D-galactosamine/lipopolysaccharide (D-GalN/ LPS).