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Disease is any harmful deviation from the normal structural or functional state of an organism, generally associated with certain signs and symptoms. One of the most important tropical infectious disease is dengue. Dengue fever is commonly known as ‘Break Bone Fever’. It is an infectious disease caused by a virus Arbovirus from the genus Flavivirus. It is transmitted by mosquito, Aedes aegypti closely associated with human habitation. Dengue fever is caused by four antigenically related but distinct dengue virus transmitted by infected mosquitoes.