Open AccessSynthesis and Characterization of Gellan Gum-Pyridoxine Nanoparticle for Treatment of Localized Peripheral Neuropathy
Author(s) -
R Vigneshwaran,
Mamilla Ravi Sankar,
S. Vigneshkumar
Publication year - 2019
Publication title -
international journal of engineering and advanced technology
Language(s) - English
Resource type - Journals
ISSN - 2249-8958
DOI - 10.35940/ijeat.a1127.1291s419
Subject(s) - gellan gum , biopolymer , pyridoxine , nanoparticle , chemistry , methylene blue , materials science , nuclear chemistry , organic chemistry , nanotechnology , biochemistry , food science , polymer , photocatalysis , catalysis
Biopolymer has full application as a drug carrier and scaffold in tissue engineering because of its biodegradability and non-toxicity. The present study is focused on novel biopolymer gellan gum as a drug delivery agent. The objective of the study is to synthesize the gellan gum nanoparticle by solvent evaporation emulsification method and characterize it using SEM, DLS, FTIR, and XRD. As pyridoxine is effectively used to treat diabetic peripheral neuropathy, it has been encapsulated with gellan gum and characterized. The antioxidant assay was performed using ABTS reagent, and the activity increases with increasing concentration of nanoparticle. Also, it has significant antimicrobial activity against gram-positive bacteria. Apart from this, the drug release kinetics of the gellan gum- pyridoxine nanoparticle was studied.