Open AccessEffects of Dexamethasone on the Course of Intoxication when Modelling Mustard Gas Inhalation Injury
Author(s) -
Katrina Bulka,
С. П. Сидоров,
О. В. Чубарь,
Mait Metelitsa
Publication year - 2020
Publication title -
biomedicina
Language(s) - English
Resource type - Journals
eISSN - 2713-0428
pISSN - 2074-5982
DOI - 10.33647/2074-5982-16-3-111-114
Subject(s) - dexamethasone , inhalation , sprayer , regimen , medicine , anesthesia , pharmacology , surgery , biology , agronomy
The current work assesses the efcacy of a course of intramuscular administration of dexamethasone at doses of 1 or 4 mg/kg when modelling sulphur mustard aerosol inhalation injury. To this end, the average lethal doses, the median death time and the protection coefcients were calculated for rats with sulphur mustard inhalation injury induced by a micro-sprayer. In the treatment regimen used, dexamethasone showed low levels of efcacy, possibly due to its pleiotropic effect on the immune system.