Open AccessDiagnostics and Treatment of Hyperplastic Endometrial Processes in Women in the Menopausal Transition
Author(s) -
Svetlana Abramova,
Olga Victorovna Gladkova,
L. Zaidulina,
I. Syatkina,
E. Surgaeva
Publication year - 2019
Publication title -
bûlletenʹ nauki i praktiki
Language(s) - English
Resource type - Journals
ISSN - 2414-2948
DOI - 10.33619/2414-2948/42/09
Subject(s) - endometrium , hyperplasia , menopause , endometrial hyperplasia , hormone , hormone therapy , medicine , pathological , estrogen , immunohistochemistry , gynecology , cancer , breast cancer
His article discusses the problems of diagnosis of diffuse hyperplastic processes of the endometrium in women in the menopausal transition. Endometrial hyperplasia is a heterogeneous set of pathological processes, ranging from benign proliferation to monoclonal tissue proliferation. During the study, the most optimal criteria for the diagnosis of endometrial hyperplasia in women during the transition to menopause based on the use of a modern diagnostic complex (immunohistochemical and endoscopic technologies) were selected and formed. Endometrium is a hormone–sensitive, cyclically renewed tissue that reacts to the slightest changes in the hormonal status. In this connection, an attempt was made to analyze the prospects and feasibility of using immunohistochemical technologies in gynecological practice. The authors found that the study and analysis of the hormone — receptor status in individuals with endometrial hyperplasia in gynecological practice, consists of two points, first, the hormone-receptor status in endometrial hyperplasia is individual, and the degree of expression of highly productive or low-productive receptor complexes speaks the mechanism of development of receptor desynchronosis, and secondly, the hormone-receptor status determines the sensitivity of endometrial hyperplasia to hormonal therapy.