Open AccessUse of hyperbaric oxygen therapy in the treatment of osteoradionecrosis of the maxilla in patients with head and neck cancer
Author(s) -
Lucas Andeilson dos Santos Matos,
Mauro Wilker Cruz de Azevedo,
Rafaela Alves Castro,
Carla Natiara Rabelo Mesquita,
Antonio Ítalo de Souza Sampaio,
Samara Lima Rabelo,
Lauana Kelly Cavalcante Mendes,
Maria Karolina de Freitas Queiroz,
Jonatan Costa Gomes
Publication year - 2022
Publication title -
research, society and development
Language(s) - English
Resource type - Journals
ISSN - 2525-3409
DOI - 10.33448/rsd-v11i2.25750
Subject(s) - osteoradionecrosis , medicine , head and neck cancer , radiation therapy , hyperbaric oxygen , head and neck , hypoxia (environmental) , cancer , cancer therapy , surgery , oxygen , chemistry , organic chemistry
This study aimed to understand how hyperbaric oxygen therapy can act in the treatment of osteoradionecrosis of the jaws in patients with head and neck cancer. A total of 266 publications were found. After applying the inclusion and exclusion criteria, 19 articles were selected. Osteoradionecrosis is a condition with great potential for bone destruction, and therefore, many methods for treatment have been vehemently studied. Although the mechanism of action of hyperbaric oxygen therapy is not fully understood, it is known that the physiochemistry that drives the action is a result of two factors: 100% inspired oxygen and exposure to high atmospheric pressure. In addition, oxygen when present in larger quantities in the body can act to heal necrotic regions, oxygenating regions where hypoxia and hypoperfusion have occurred. However, this therapy is not totally innocuous and has significant issues for the patient, among them, the limitation of its access, and with this, the cost for oxygen therapy is very high. The negative impact that osteoradionecrosis has on oncology patients can be seen, and how hyperbaric therapy can act in the treatment of necrosis caused by oncotherapy in patients with head and neck cancer, due to its numerous effects on oxidative metabolism. In contrast, it is necessary to correctly evaluate the indication of the treatment, because the therapy has relevant adverse effects that deserve attention.