Open AccessPreparation of metal doped quercetin nanoparticles, characterization and their stability study
Publication year - 2019
Publication title -
letters in applied nanobioscience
Language(s) - English
Resource type - Journals
ISSN - 2284-6808
DOI - 10.33263/lianbs84.704710
Subject(s) - solubility , scanning electron microscope , materials science , amorphous solid , nanoparticle , doping , metal , nuclear chemistry , energy dispersive x ray spectroscopy , chemical engineering , analytical chemistry (journal) , chemistry , nanotechnology , crystallography , chromatography , metallurgy , composite material , optoelectronics , engineering
The purpose of this study was to develop metal-loaded (Zn, Cu) quercetin nanoparticles (M-QNPs) using a nanoprecipitation method for the investigation of solubility and stability of QNPs and their metal doped NPs (M-QNPs) in acidic condition. The QNPs and M-QNPs were characterized by using UV-visible and FT-IR spectroscopy, X-ray diffraction, UPLC-DAD, scanning electron microscopy (SEM) and energy dispersive X-ray (EDAX) analysis. The XRD and SEM results of QNPs showed the conversion of the amorphous state of the drug to the crystalline state. The microscopic results demonstrate that the QNPs and M-QNPs showed rod shaped structure which ascribed to a different degree of solubility and stability. In conclusion, the metal doped QNPs improved its stability in acidic condition, but the solubility of M-QNPs was better than that of QNPs which could be used as trace elements supplement for micro-nutrient.