Open AccessCancer testis antigens in newly diagnosed and relapse multiple myeloma: prognostic markers and potential targets for immunotherapy
Author(s) -
Mark van Duin,
Annemiek Broyl,
Yvonne de Knegt,
Hartmut Goldschmidt,
Paul G. Richardson,
Wim C. J. Hop,
Bronno van der Holt,
Débora Joseph-Pietras,
George Mulligan,
Rachel Neuwirth,
Surinder S. Sahota,
Pieter Sonneveld
Publication year - 2011
Publication title -
haematologica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.782
H-Index - 142
eISSN - 1592-8721
pISSN - 0390-6078
DOI - 10.3324/haematol.2010.037978
Subject(s) - antigen , cancer , multiple myeloma , medicine , oncology , immunotherapy , cancer research , biology , immunology
In multiple myeloma, expression of cancer testis antigens may provide prognostic markers and potential targets for immunotherapy. Expression at relapse has not yet been evaluated for a large panel of cancer testis antigens which can be classified by varying expression in normal tissue: restricted to testis, expressed in testis and brain and not restricted but selectively expressed in testis.