Inhibition of Fibroblast Apoptosis by Borrrelia afzelii, Coxiella burnetii and Bartonella henselae | Zendy

Tomasz Chmielewski | Zendy; Stanisława Tylewska-Wierzbanowska | Zendy

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Inhibition of Fibroblast Apoptosis by Borrrelia afzelii, Coxiella burnetii and Bartonella henselae

Author(s) -

Tomasz Chmielewski,

Stanisława Tylewska-Wierzbanowska

Publication year - 2011

Publication title -

polish journal of microbiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.312

H-Index - 34

eISSN - 2544-4646

pISSN - 1733-1331

DOI - 10.33073/pjm-2011-038

Subject(s) - coxiella burnetii , bartonella henselae , apoptosis , biology , bartonella , cat scratch disease , borrelia afzelii , microbiology and biotechnology , programmed cell death , intracellular parasite , virology , immunology , disease , antibody , borrelia , immune system , borrelia burgdorferi , serology , medicine , pathology , biochemistry

Apoptosis is a genetically controlled mechanism of cell death involved in the regulation of tissue homeostasis. The aim of this study was to investigate the influence of Borrelia afzelii, Coxiella burnetii, and Bartonella henselae bacteria on apoptosis measured as the level of caspase 3 activity in human fibroblast cells HEL-299. Our findings show that C. burnetii bacteria may inhibit the process of apoptosis in the host cells for a long time. This can permit intracellular survival in the host and mediatingthe development of chronic disease.

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