Open AccessEffect of Mexidol-Vet® on the course and outcome of acute radiation injury in rats
Author(s) -
Roman Vasilev
Publication year - 2020
Publication title -
russian veterinary journal
Language(s) - English
Resource type - Journals
ISSN - 2500-4379
DOI - 10.32416/2500-4379-2020-5-31-37
Subject(s) - leukocytopenia , medicine , erythropoiesis , drug , pharmacology , antioxidant , therapeutic effect , radiation injury , chemistry , radiation therapy , anemia , toxicity , biochemistry
This paper presents experimental data on the effect of the drug Mexidol-Vet® on the course and outcome of acute radiation damage in rats caused by a single, general, external gamma radiation. There was a 20 % decrease in mortality in animals relative to the control values, activation of erythropoiesis, and a decrease in the severity of erythrocytopenia, leukocytopenia, and thrombocytopenia with the use of Mexidol-Vet®. The supposed mechanism of radioprotective and therapeutic action is the pronounced antioxidant and membrane-protective properties of the drug.
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