Open AccessEffect of sildenafil citrate on prediabetic and diabetic albino rats treated with metformin
Author(s) -
ahmed mohmed taha,
Haredy Hassan Haredy,
Ahmed Ghareip,
Ahmed El sayed Nour el-deen,
Yasser Ashour
Publication year - 2021
Publication title -
international journal of current research in physiology and pharmacology
Language(s) - English
Resource type - Journals
eISSN - 2523-6709
pISSN - 2523-6695
DOI - 10.31878/ijcrpp.2021.51.02
Subject(s) - sildenafil , metformin , medicine , biguanide , streptozotocin , diabetes mellitus , endocrinology , cgmp specific phosphodiesterase type 5 , cyclic guanosine monophosphate , prediabetes , glycemic , type 2 diabetes , pharmacology , nitric oxide
Diabetes Miletus (DM) is a global epidemic disease. It is estimated that there are already 415 million adults aged 20–79 years diabetics worldwide. Sildenafil citrate is a phosphodiesterase type 5 (PDE5) inhibitor, which increases cyclic guanosine monophosphate (cGMP) and metformin (MET) is a biguanide used for the treatment of type 2 diabetes which increases peripheral insulin sensitivity.Aim: This study aims to assess the effect of sildenafil citrate and metformin on lipid profile and glycemic control in diabetic and prediabetic albino rats.Materials and methods: Adult male albino rats are used and divided into nine groups each group consists of 10 rats, diabetes is induced by feeding a high-fat diet (HFD) for an initial period of 2 weeks followed by a single intraperitoneal injection of (35 mg/kg) Streptozotocin. Prediabetes is induced by feeding (HFD) and glucose in water for a period of 2 weeks. Sildenafil was given in a dose of (5 &10 mg/kg/day orally for 4 weeks), metformin was given in a dose of (50 &100 mg/kg/day orally for 4 weeks) using oral gavages to normal healthy rats, diabetic and prediabetic rats. Blood samples were collected after 4 weeks of treatment in all experimental groups.Results: Combined administration of sildenafil and metformin on diabetic rats improving hyperglycemia, oxidative stress, and hyperlipidemia induced by streptozotocin than the administration of metformin or sildenafil alone.Conclusion: Sildenafil has beneficial effects against some diabetic complications. The present study showed that sildenafil with metformin has beneficial effects against diabetic complications.