Open AccessIntroduction of HER-2 and a Short Review on Its Role in Prognosis and Treatment of Breast Cancer
Author(s) -
Seyed Abbas Mirmalek,
Fatemeh Elhamkani,
Seyed Alireza Salimi Tabatabaee,
Hashem Mahmoodzadeh,
Yekta Parsa,
Soheila Yadollah-Damavandi,
Ehsan Jangholi
Publication year - 2014
Publication title -
galen medical journal
Language(s) - English
Resource type - Journals
eISSN - 2588-2767
pISSN - 2322-2379
DOI - 10.31661/gmj.v3i3.318
Subject(s) - medicine , breast cancer , oncology , epidermal growth factor receptor , cancer , oncogene , epidermal growth factor , human epidermal growth factor receptor 2 , breast carcinoma , metastasis , cancer research , receptor , cell cycle
Human Epidermal growth factor Receptor-2 (HER-2) as a new prognostic and predictive factor has been believed as an essential measurement in breast carcinoma. About 280 articles were reviewed and 115 were referred in this review article on HER-2. HER-2 is an oncoprotein epidermal growth factor receptor produced by a so-called cell surface oncogene. Overexpression results in aggressive behavior, early metastasis to lymph nodes and distant areas, and poor prognosis in breast cancer. HER-2 seems to be a prognostic and predictive factor and must be considered in all breast cancer cases.