Open AccessDETERMINATION OF THE OPTIMAL DOSE OF THE COMPLEX AGENT Z-88
Author(s) -
Z.F. Aukhadieva
Publication year - 2021
Publication title -
učenye zapiski kazanskoj gosudarstvennoj akademii veterinarnoj mediciny im. n.è. baumana
Language(s) - English
Resource type - Journals
ISSN - 2413-4201
DOI - 10.31588/2413-4201-1883-246-2-10-13
Subject(s) - body weight , zoology , toxicology , medicine , biology
The article is devoted to determining the optimal dose of the complex agent Z-88. The ex-periments were conducted on young mongrel white rats. It was found that intramuscular injections of the drug at a dose of 5.0 ml/kg of body weight inhibited the growth and development of experi-mental animals. The best growth and development indicators were established in the second exper-imental group when using the drug, the share of which was 1/20 of the maximum introduced in the experiment for determining the parameters of acute toxicity. In this group, the average daily weight gain at the end of the experiment was 2.23 g. with 1.67 g. in the control; a relative increase of 95.2 %, for the entire period, the body weight reached 121.0 g., which is 18.3% higher than the control.