Open AccessVASCULAR ENDOTHELIAL GROWTH FACTOR AND HLA-PHENOTYPE IN PATIENTS WITH CHRONIC GLOMERULONEPHRITIS
Author(s) -
М. Kolesnyk,
V. Driianska,
М. Velychko,
G.N. Drannik,
V. Nepomnyaschiy,
V. Savchenko,
F Z Gaĭseniuk
Publication year - 2016
Publication title -
ukraïnsʹkij žurnal nefrologìï ta dìalìzu
Language(s) - English
Resource type - Journals
eISSN - 2616-7352
pISSN - 2304-0238
DOI - 10.31450/ukrjnd.3(51).2016.01
Subject(s) - human leukocyte antigen , medicine , vascular endothelial growth factor , antigen , typing , immunology , tissue typing , phenotype , glomerulonephritis , nephrotic syndrome , vegf receptors , biology , kidney , biochemistry , gene , genetics
It was to determine associations the serum levels ofVEGF and with HLA inpatients with chronic glomerulonephritis and nephrotic syndrome (CGN, NS).
Materials and methods. There was studied the serum levels of VEGF (80 patients) by ELIZA and HLA-antigens distribution in the CGN, NS patients (534) by typing the lymphocytes with the aid of standard microlymphocytotoxic test (Terasaki’s test). The diagnosis was confirmed morphologically using by nephrobiopsy.
Results. The distribution of HLA-A, В antigens of the 2 group patients having the CGN, NS with various serum levels of VEGF is shown. Associations of some HLA-antigens and high levels of vascular endothelial growth factor in blood were noted.
Conclusion. High serum level VEGF and HLA-A9, A10 (25+26) and B8 in CGN, NS patients associated with steroidoresistence.