Open AccessBacterial vaginosis and cervical intraepithelial neoplasia
Author(s) -
PlatzChristensen Jens Jörgen,
Sundström Eva,
Larsson PerGöran
Publication year - 1994
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016349409006278
Subject(s) - bacterial vaginosis , cervical intraepithelial neoplasia , medicine , carcinoma in situ , gynecology , papanicolaou stain , carcinoma , intraepithelial neoplasia , pap smears , gastroenterology , cervical cancer , cancer , prostate
Methods . In an attempt to investigate an association between the finding of clue cells in Papanicolaou‐stained (PAP) smears and cervical intraepithelial neoplasia (CIN), a total of 6I50 smears from 1976 were re‐investigated. Results . Clue cells representing bacterial vaginosis were present in 10% of the PAP‐smears. CIN II and III alone, as well as all CIN cases, were more common in women with bacterial vaginosis ( p < 0.001). Histologically CIN III/carcinoma in situ was found in nine patients with and in 16 patients without bacterial vaginosis. The relative risk of having CIN III/ carcinoma in situ if the women had bacterial vaginosis was 5.0 with 95% confidence interval of 2.2‐11.6. Conclusions . The possibility exists that bacterial vaginosis is in some way associated with the development of cervical intraepithelial neoplasia, i.e. as a cofactor to human papilloma virus. Therefore. bacterial vaginosis must be taken in consideration in future studies on CIN.