Open AccessNon‐Steroid Hormones and Tissue Polypeptide Antigen (TPA) in Emetic and Non‐Emetic Pregnancy
Author(s) -
JärnfeltSamsioe Ann,
Bremme Katarina,
Eneroth Peter
Publication year - 1986
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348609161494
Subject(s) - pregnancy , nausea , vomiting , medicine , hyperemesis gravidarum , hormone , prolactin , endocrinology , human chorionic gonadotropin , endocrine system , physiology , biology , genetics
In order to investigate further the endocrine and metabolic features of the common condition emesis gravidarum, serum concentrations of some non‐steroid hormones and tissue polypeptide antigen (TPA) were determined in 102 healthy pregnant women. 62 complained of nausea and vomiting in early pregnancy. Significantly higher and lower levels of human chorionic gonadotropin were noted in early and late pregnancy, respectively, in women with emesis gravidarum. A significant rise in serum prolactin and TPA was found throughout pregnancy in all subjects, no differences between emetic and non‐emetic pregnancies being registered. Serum concentrations of growth hormone (hGH) showed a significant decline as pregnancy advanced. Emetic women demonstrated higher hGH levels in late pregnancy than did asymptomatic subjects. Free T 4 concentrations remained stable when comparing early with late pregnancy, no dissimilarities being found between women with and without nausea and vomiting in pregnancy. These data do not support the hypothesis of major metabolic disturbances as an etiologic factor for nausea and vomiting in pregnancy. However, as overt differences between emetic and non‐emetic pregnancy were found, hormonal factors may be involved in the pathogenesis of this condition.