Open AccessSingle Extra‐Amniotic Injection of Prostaglandin E 2 in Tylose Gel to Induce First Trimester Abortion in Young Nullipara
Author(s) -
Djahanbakhch O.,
Bassan T. S.,
Marshall D. E.,
Gardner N. H.
Publication year - 1982
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016348209156588
Subject(s) - medicine , abortion , obstetrics , prostaglandin e2 , gynecology , amniotic fluid , pregnancy , prostaglandin , fetus , biology , genetics
. A single extra‐amniotic injection of 2 or 4 mg of prostaglandin E 2 in Tylose gel was administerd to 30 primi‐gravidae between the ages of 14 and 20 years to induce first‐trimester abortion. Twenty‐three patients (76.7%) aborted, though incompletely, within 9 hours, with a mean induction‐abortion interval of 6.3 hours. In the remaining 7 (23.3%) the cervical os was found to be open and no mechanical dilatation was required at the time of vacuum aspiration. The only side effect was vomiting, which occurred in 2 patients. The method was shown to be safe and effective and may be employed in young primigravidae, thus eliminating the cervical complications attending vacuum aspiration.