Open AccessMalignant Trophoblastic Neoplasia
Author(s) -
Kolstad Per,
Høeg Kari,
Norman Nils
Publication year - 1972
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347209156858
Subject(s) - medicine , choriocarcinoma , methotrexate , chemotherapy , chorioepithelioma , radioimmunoassay , oncology , gynecology , gastroenterology
Malignant trophoblastic neoplasia is uncommon in Scandinavia, only 4–5 cases per 100 000 live births being reported to the National Cancer Registries each year. In a small series comprising 30 patients the effectiveness of chemotherapy in curing non‐metastatic as well as metastatic disease was confirmed. Of 16 women with metastatic choriocarcinoma, 12 were cured by combined treatment with methotrexate and actinomycin D. In the monitoring of treatment and follow‐up of the patients radioimmunoassay of LH in serum was found more sensitive and reliable than determination of HCG in 24‐hour urine. A delayed response to chemotherapy with fluctuating hormone levels during chemotherapy was observed to be of prognostic and therapeutic significance.