Open AccessChromosome Pattern in a Patient with Cervical Carcinoma in situ and Atypical Hyperplasia of the Endometrium
Author(s) -
Granberg Ingrid,
Traneus Anders,
Silfverswärd Claes
Publication year - 1972
Publication title -
acta obstetricia et gynecologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.401
H-Index - 102
eISSN - 1600-0412
pISSN - 0001-6349
DOI - 10.3109/00016347209154967
Subject(s) - carcinoma in situ , medicine , dysplasia , endocervical curettage , pathology , endometrium , carcinoma , curettage , malignancy , atypical hyperplasia , biopsy , endometrial hyperplasia , hyperplasia , gynecology , colposcopy , cervical cancer , cancer , obstetrics
This report concerns a patient with preinvasive cervical carcinoma and atypical hyperplasia in the endometrium. Separate chromosome analyses were performed on foci of moderate dysplasia and carcinoma in situ in a cone biopsy, and on material obtained from two curettage specimens. The chromosome picture in the two cervical areas differed and indicated a clonal evolution. The two curettage specimens were at variance with the cervical epithelium. The cytogenetic difference between squamous and columnar dysplasia is discussed in relation to the possible pathway of development of malignancy.