Open Access43 Natural Anticancer Products: Classified under the Cancer Hallmarks and the Available Evidence of their Anticancer Activities
Author(s) -
Dwight L. McKee,
Mamoona S. Lodhi
Publication year - 2021
Publication title -
journal of cancer research updates
Language(s) - English
Resource type - Journals
eISSN - 1929-2279
pISSN - 1929-2260
DOI - 10.30683/1929-2279.2021.10.08
Subject(s) - cancer , natural (archaeology) , cancer therapy , natural product , computational biology , biology , biochemistry , genetics , paleontology
About 60% of chemotherapeutic agents used for the treatment of cancer diseases today have been derived from natural products. While some of these agents are identical to the natural molecules found in plants; the others are semisynthetic derivative of the foundational molecule found naturally in the raw sources. Cancers have been reported to express 10 specific hallmark which are used as the key points or steps for targeted therapy against these cancers. Extending the number of these hallmarks to 12 this review article throws light on 43 natural products classifying them according to their target of action. Further, the natural products under consideration are categorized according to the level of evidence present for their anticancer activities.