Open AccessALCOHOLIC LIVER DISEASE (ALD)
Author(s) -
Muhammad Saeed Qureshi,
Rizwan Ahmad,
Razia Rizwan,
Arif Malik,
Abdul Manan,
Mahmood Husain Qazi,
Sumaira Shaheen
Publication year - 2015
Publication title -
the professional medical journal/the professional medical journal
Language(s) - English
Resource type - Journals
eISSN - 2071-7733
pISSN - 1024-8919
DOI - 10.29309/tpmj/2015.22.07.1179
Subject(s) - medicine , alcoholic liver disease , catalase , gastroenterology , oxidative stress , alcohol , alcohol consumption , alcohol abuse , chronic alcoholic , lipid peroxidation , kidney , lipid profile , liver disease , kidney disease , biochemistry , cholesterol , psychiatry , biology , cirrhosis
Objective: The aim of the present study was to investigate the changes inbiochemical parameters including lipid profile, liver and kidney profile as well as oxidative stressprofile, particularly in patients suffering from alcoholic liver disease (ALD). Study design: Fiftychronic alcoholics admitted for treatment to the in-patient wards at Jinnah Hospital, Lahore-Pakistan. Chronic alcoholics with alcohol abuse for more than four to five years, and with orwithout clinical complications, were included. Apparently twenty healthy individuals servedas control. Period: 2012-2013. Materials and methods: Various circulating biochemicalbiomarkers including renal profile, hepatic and lipid profile were evaluated. Moreover, stressmarkers (MDA. SOD, GSH and catalase) were also investigated. Results: A very strong directand indirect correlation of ALP was found with TB, MDA and GSH (r=.950**, r=.929** and r=-.967** respectively, P<0.01). MDA was observed having very strong indirect correlation withGSH and catalase (r=-.909** and r=-.777** respectively, P<0.01). Conclusion: All parametersin combinations may be useful indicator or may be good and reliable biochemical markers foridentification and determination of severity of alcoholic liver diseases (ALD). The damagingof hepatocytes due to the consumption of alcohol disturbs almost all types of biochemicalcoordination in the biological system.