Open AccessH2 RECEPTOR ACTIVITY
Author(s) -
Naseer Khan Baloch,
Nusrat Jafri,
Ahmed Danyal
Publication year - 2018
Publication title -
the professional medical journal/the professional medical journal
Language(s) - English
Resource type - Journals
eISSN - 2071-7733
pISSN - 1024-8919
DOI - 10.29309/tpmj/2014.21.05.2499
Subject(s) - cimetidine , inotrope , histamine , histamine h2 receptor , medicine , antagonist , receptor , pharmacology , endocrinology , receptor antagonist , histamine receptor
… Histamine can stimulate the heart by directly interacting with cardiac histaminereceptors. In the present study we have investigated the H2 receptor activity in isolated rabbitheart. Cimetidine, a specific H2 receptor antagonist was used. The isolated heart was mountedin langendroff apparatus. The heart was perfused at a constant pressure with oxygenatedRinger‘s Locke solution. H2 receptor antagonist produces negative inotropic effect in thepresence of histamine. This indicates that H2 receptors are present in rabbit heart, and plays arole in mediation of positive inotropic effect produced through CAMP by histamine.