Open AccessEfektivitas HE4 sebagai Metode Skrining Terbaru untuk Diagnosis Dini Kanker Ovarium
Author(s) -
Amru Sofian,
Hendra Perkasa,
Ega Rahman Evsya,
Riyan M Darundryo
Publication year - 2017
Publication title -
jurnal ilmu kedokteran /jurnal ilmu kedokteran
Language(s) - English
Resource type - Journals
eISSN - 2715-4467
pISSN - 1978-662X
DOI - 10.26891/jik.v5i2.2011.88-93
Subject(s) - epididymis , ovarian cancer , biomarker , medicine , cancer , gynecology , andrology , oncology , biology , sperm , biochemistry
The tumor marker CA125 is one of the currently used biomarkers to detect ovarian cancer. The tumormarker CA125 also elevated in other diseases. Human epididymis protein 4 is used as a new biomarker forearly detection of ovarian cancer. Human epididymis protein 4 is increased in almost all patients withovarian cancer and increased only slightly at a fraction of other diseases. Human epididymis protein 4 hasa better effectiveness in detecting ovarian cancer when combined with CA125. From the study of literaturefound that the combination of HE4 and CA125 had a specificity of 96.3% and 92.9% sensitivity.