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This review is devoted to the 25th anniversary of the beginning of the widespread use of the prototype of “respiratory” fluoroquinolones levofloxacin in clinical practice. The article presents the evidence of clinical and microbiological efficacy, as well as good tolerability of levofloxacin obtained during numerous clinical studies, as well as evidence of long-term successful use of the antibiotic in real clinical practice, which determines its unique place in modern schemes of antibacterial therapy of adult patients with community-acquired lower respiratory tract infections.

Levofloxacin in the treatment of community-acquired infections of the lower respiratory tract: a look through a quarter of a century