Open AccessEvaluation of the clinical efficacy of local antibacterial therapy in the treatment of acute bacterial rhinosinusitis
Author(s) -
T. V. Banashek-Meshcheryakova,
F V Semyonov
Publication year - 2020
Publication title -
terapevtičeskij arhiv
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.181
H-Index - 14
eISSN - 2309-5342
pISSN - 0040-3660
DOI - 10.26442/00403660.2020.12.000834
Subject(s) - medicine , tolerability , clinical efficacy , clinical trial , antimicrobial , antibiotics , sinusitis , pathological , pharmacotherapy , surgery , adverse effect , chemistry , organic chemistry , microbiology and biotechnology , biology
Aim.To evaluate the clinical efficacy of Polydexa with phenylephrinum in the complex treatment of moderate acute bacterial rhinosinusitis.
Materials and methods.The article presents the results of a clinical study of 100 patients with moderate acute bacterial rhinosinusitis 37 (37%) men, 63 (63%) women aged 15 to 53 years. The patients were randomized into 2 groups of 50 people each. In the study group, patients received systemic antibiotic therapy and a topical nasal spray of Polydexa with phenylephrinum. The control group received systemic antibacterial therapy and long-acting local decongestants. The evaluation criteria were statistically significant differences in clinical and laboratory parameters of the control and main groups.
Results and conclusion.The pronounced anti-inflammatory, antimicrobial effects of the drug were confirmed; conclusions were drawn about the clinical efficacy, tolerability, safety of Polydexa with phenylephrinum and allows to achieve complete resolution of the pathological process in more cases.