Open AccessMass Spectrometry Research at the Laboratory for Organic Chemistry, ETH Zurich
Author(s) -
Konstantin Barylyuk,
Vladimir Frankevich,
Alfredo J. Ibáñez,
Pablo Sinues,
Renato Zenobi
Publication year - 2014
Publication title -
chimia
Language(s) - English
Resource type - Journals
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/chimia.2014.119
Subject(s) - chemistry , mass spectrometry , gas phase , environmental chemistry , analytical chemistry (journal) , ionization , chromatography , nanotechnology , organic chemistry , ion , materials science
This contribution covers the most important activities of the Zenobi research group at the Organic Chemistry Laboratory, ETH Zurich. We work in a number of interrelated areas that encompass fundamental/mechanistic research, instrument and methods development, and applications. This is illustrated with examples from the mass spectrometric study of noncovalent interactions, using both native ESI and MALDI for ionization, the investigation of the gas-phase conformation of ionized bio-macromolecules, the use of ambient mass spectrometry for rapid, on-line analyses of, for example, exhaled breath, and the use of MALDI and microarray technologies for studying metabolites with extreme sensitivity, sufficient to probe the metabolites from single cells.