Open AccessSimulated Moving Bed Chromatography – The Next Step in HPLC
Author(s) -
Thomas van Oordt,
Edwin Bayliss,
Thomas Netscher,
Werner Bonrath,
Thomas Spielmann
Publication year - 2006
Publication title -
chimia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.387
H-Index - 55
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/000942906777674967
Subject(s) - simulated moving bed , adsorption , chromatography , process (computing) , separation process , separation (statistics) , process engineering , chromatographic separation , chemistry , high performance liquid chromatography , computer science , biochemical engineering , materials science , engineering , machine learning , organic chemistry , operating system
Simulated Moving Bed (SMB) technology, a continuous chromatographic separation process, is of increasing interest in the field of pharmaceuticals, fine chemicals, and biotechnology. The complexity of SMB asks for a deeper understanding of the mathematical design and physical adsorption processes, along with the practical training in chromatography and process engineering. This makes SMB a technology which is also suitable for educational purposes. The principle of SMB separation is described with a short introduction of its mathematical design for a simulation. A method of measuring the adsorption isotherms, which are crucial for a process simulation, is also discussed. As an example, the application of SMB to the separation of two groups of biologically important vitamin E compounds, i.e. tocopherols and tocotrienols from natural-source material is presented.