Open AccessThe Synthesis of a Pyrazol Analogon of Porphobilinogen with the Help of the Mukaiyama Aldol Reaction
Author(s) -
André Chaperon,
Hugo Bertschy,
Anne-Laurence Franz-Schrumpf,
Bertrand Hugelet,
Antonia Neels,
Helen Stœckli-Evans,
Reinhard Neier
Publication year - 2003
Publication title -
chimia
Language(s) - English
Resource type - Journals
eISSN - 2673-2424
pISSN - 0009-4293
DOI - 10.2533/000942903777678812
Subject(s) - porphobilinogen , retrosynthetic analysis , chemistry , aldol reaction , stereochemistry , organic chemistry , catalysis , total synthesis , enzyme
The synthesis of a pyrazol analogon of porphobilinogen is described. The Mukaiyama crossed aldol reaction is the key step of our approach. The retrosynthetic analysis follows the mechanism for the biosynthesis of porphobilinogen initially proposed by Shemin.