Open AccessEffect of Pterospermum acerifolium Willd on Inflammation and ProInflammatory Cytokines
Author(s) -
Manna K. A,
U Nanda,
Swagata Kar
Publication year - 2018
Publication title -
international journal of pharmacognosy and phytochemical research
Language(s) - English
Resource type - Journals
ISSN - 0975-4873
DOI - 10.25258/phyto.v10i01.11927
Subject(s) - croton oil , proinflammatory cytokine , inflammation , edema , pharmacology , in vivo , peripheral blood mononuclear cell , croton , tumor necrosis factor alpha , medicine , interleukin , in vitro , immunology , chemistry , cytokine , traditional medicine , biology , biochemistry , microbiology and biotechnology
In our present study, the effect of alcoholic fraction of Pterospermum acerifolium seeds on inflammation andinflammatory cytokines was evaluated in-vitro by using human peripheral blood mononuclear cells (PBMCs) and in vivoby croton oil induced mouse ear edema (acute study) and Carrageen induced rat paw edema. The extract exhibitedsignificant inhibition of the production of tumor necrotic factor- and interleukin-6 by PBMCs stimulatedlipropolysaccirides (LPS) in a dose dependent manner. The extract, at the selected dose of 150 and 300mg/kg bodyweight per oral exhibited significant dose dependent anti-inflammatory response with 27.77% and 47.17% inhibition ofinflammation in croton oil induced mouse ear edema and Carrageen induced rat paw edema respectively.
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