Open AccessBenzodiazepine Derivatives from Marine-Derived Streptomyces cacaoi 14CM034
Author(s) -
Semiha Çetinel Aksoy,
Melis Küçüksolak,
Ataç Uze,
Erdal Bedi̇r
Publication year - 2021
Publication title -
records of natural products
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.43
H-Index - 31
ISSN - 1307-6167
DOI - 10.25135/rnp.203.20.08.1766
Subject(s) - two dimensional nuclear magnetic resonance spectroscopy , natural product , chemistry , stereochemistry , streptomyces , antimicrobial , carbon 13 nmr , organic chemistry , bacteria , biology , genetics
7-methoxy-8-hydroxy cycloanthranilylproline (2), a new natural product with pyrrolobenzodiazepine (PBD) framework, was isolated from marine-derived actinobacterium Streptomyces cacaoi 14CM034, together with cycloanthranilylproline (1). Structural elucidation of the compounds was based on FTIR, 1D- (1H and 13C NMR), 2D-NMR (COSY, HMBC and NOESY) and HR-MS analyses. Compounds 1 and 2 exhibited notable antimicrobial activity. The presence of PBD derivatives in S. cacaoi was first demonstrated with this study.
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