Open AccessSynthesis and characterization of novel mono, bis and tris heteroaryl chalcone derivatives of 1,3,5-trimethoxybenzene
Author(s) -
M. Fatih Polat,
Derya Aktaş Anı
Publication year - 2021
Publication title -
organic communications
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.238
H-Index - 15
ISSN - 1307-6175
DOI - 10.25135/acg.oc.95.21.01.1942
Subject(s) - chalcone , chemistry , tris , condensation , condensation reaction , organic chemistry , elemental analysis , combinatorial chemistry , medicinal chemistry , catalysis , biochemistry , physics , thermodynamics
In this study, a new series consisting of 12 heteroaryl chalcone derivatives of 1,3,5-trimethoxybenzene were synthesised. Chalcones were synthesised in high purity and efficiency, via condensation of mono, bis and tris 2,4,6-trimethoxy acetophenones with hetero-2-carbaldehyde derivatives based on Claisen Schdmit condensation. The reactions feature a good scope for the all products, mild reaction conditions and good yields. The synthesized compounds were characterized by using FT-IR, NMR and elemental analysis spectroscopic techniques.