Open AccessCycloaddition reactions of 4-phenyl-3H-1,2,4-triazole-3,5(4H)-dione (PTAD) and 4-methyl-3H-1,2,4-triazole-3,5(4H)-dione (MTAD): A short review
Author(s) -
Nataliya Korol,
Mikhailo Slivka,
Oksana M. Holovko-Kamoshenkova
Publication year - 2020
Publication title -
organic communications
Language(s) - English
Resource type - Journals
ISSN - 1307-6175
DOI - 10.25135/acg.oc.88.20.11.1870
Subject(s) - cycloaddition , triazole , chemistry , 1,2,3 triazole , 1,2,4 triazole , medicinal chemistry , organic chemistry , catalysis
The sources, describing cycloaddition reactions with the participation of 4-phenyl-3H-1,2,4-triazole-3,5(4H)-dione (PTAD) and 4-methyl-3H-1,2,4-triazole-3,5(4H)-dione (MTAD) were reviewed from the middle 1970s and they are mentioned in chronological order. It was noted that the most investigated are Diels-Alder reactions and cycloaddition to a few cyclic mono- and dienes. Stereochemistry of obtained products are also described.