Open AccessThe Effects of Ginsenoside Rg2 on Trastuzumab-Induced Cardiotoxicity
Author(s) -
Xiaoyong Qi
Publication year - 2021
Publication title -
alternative complementary and integrative medicine
Language(s) - English
Resource type - Journals
ISSN - 2470-7562
DOI - 10.24966/acim-7562/100179
Subject(s) - cardiotoxicity , apoptosis , pharmacology , trastuzumab , ginsenoside , chemistry , toxicity , caspase 3 , medicine , programmed cell death , biochemistry , cancer , pathology , alternative medicine , breast cancer , ginseng
Ginsenoside Rg2 inhibited the deterioration of cardiac function in rats, ginsenoside Rg2 inhibited cardiomyocyte apoptosis, increased the expression of Caspase-3,Caspase-9 and BAX in cell experiment. Conclusions: Ginsenoside Rg2 could protect cardiomyocytes in TZM-induced toxicity and it might be via inhibiting cell apoptosis.
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