Open AccessThe study of the moisture absorption properties of cathiazine
Author(s) -
Olena I. Cherniaieva,
Ivan S. Gritsenko
Publication year - 2021
Publication title -
žurnal organìčnoï ta farmacevtičnoï hìmìï
Language(s) - English
Resource type - Journals
eISSN - 2518-1548
pISSN - 2308-8303
DOI - 10.24959/ophcj.21.234270
Subject(s) - relative humidity , moisture , critical relative humidity , absorption (acoustics) , humidity , active ingredient , chemistry , materials science , composite material , organic chemistry , meteorology , medicine , pharmacology , geography
Aim. To study the moisture absorption properties of cathiazine – a new synthetic substance stimulating spermatogenesis and possessing hepatoprotective properties.Materials and methods. The kinetics of the moisture absorption capacity (hygroscopicity) was determined using the weight method at relative ambient humidity of 44 % and 75 % at a temperature of (25 ± 2) °С.Results and discussion. The weight gain of three batches of the substance cathiazine under research during the whole experiment under relative humidity conditions of 44 % was in the range from 0 to 0.041 %; when increasing humidity the percentage of the weight gain ranged from 0 to 0.082 %. Thus, the hygroscopicity of the active pharmaceutical ingredient cathiazine in all three batches can be described as insignificant.Conclusions. The results obtained indicate that the cathiazine original substance is non-hygroscopic, and this fact can be used in the development of a pharmacopoeial monograph.