Open AccessmicroRNA-based diagnostic and therapeutic opportunities in lung cancer
Author(s) -
Jianfei Zhao,
Yan Cai,
Lifeng Xi
Publication year - 2015
Publication title -
microrna diagnostics and therapeutics
Language(s) - English
Resource type - Journals
ISSN - 2084-6843
DOI - 10.2478/micrnat-2014-0006
Subject(s) - microrna , lung cancer , carcinogenesis , pathological , cancer , non coding rna , biology , bioinformatics , gene , cancer research , computational biology , medicine , oncology , pathology , genetics
microRNAs (miRNAs) are a class of non-codingRNA which suppress target gene expression. miRNAs areinvolved in most physiological and pathological process,including carcinogenesis. miRNA expression profiles help toimprove lung cancer diagnosis, classification and prognosticinformation. Tumor suppressive and oncogenic miRNAs havebeen discovered and their functions have been investigated.Emphasis is placed on the development of miRNA-basedmethods for lung cancer diagnosis and therapy and futuredirections are proposed