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Summary 				 Background: Hyperhomocysteinemia (HHcy) may be corre- lated with cognitive function. Although intervention with folic acid and VitB 1 2  can  decrease the homocysteine (Hey) level, its effect on cognitive function remains uncertain. This prospective study aimed to explore the effects of folic acid and VitB/!2  on  the ^су  an&lt; ^ cognitive function in patients with vascular cognitive impairment-no dementia (VCIND) complicated with HHcy.  				 Methods: A total of 120 patients with VCIND complicated fcy HHcy were randomly selected. They were divided into inter- vention and control groups. The intervention group was given 5 mg of folic acid per day and 500 цд of VitB^ thrice per day apart from conventional therapy. Folic acid, V'itB l2 , and Hey were determined and Montreal cognitive assess- ment (MoCA) and event-related potential P300 determination were performed before and after treatment.  				 Results: Before treatment, no significant differences in the folic acid, VitB^, Hey, MoCA, and P300 parameters were observed between the groups. After treatment, the folic acid and VitB l2  levels increased and the Hey level decreased in the intervention group compared with that before treatment and in the control group. At 24 weeks, the MoCA score and P300 outcomes in the intervention group improved com- pared with those before treatment and in the control group.  				 Conclusions: Folic acid and VitB^ effectively decrease the Hey level in VCIND patients and improve their cognitive functions.

journal of medical biochemistry

INTERVENTION EFFECT OF FOLIC ACID AND VITAMIN B12 ON VASCULAR COGNITIVE IMPAIRMENT COMPLICATED WITH HYPERHOMOCYSTEINEMIA / EFEKAT INTERVENCIJE FOLNOM KISELINOM I VITAMINOM B12 NA VASKULARNI KOGNITIVNI POREMEĆAJ KOMPLIKOVAN HIPERHOMOCISTEINEMIJOM