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Purpose. The present study investigated whether L-arginine supplementation reduces blood pressure (BP) in hypertensive subjects with different ACE genotypes. Methods. Eight male hypertensive patients received L-arginine (2 or 4 g/day) or a placebo for a period of 4 days prior an exercise test. Statistical analysis consisted of one-way analysis of variance. Results. L-arginine supplementation induced a statistically significant (p ⋋ 0.05) reduction in systolic BP measured during rest (reductions of 7.8% and 12.3% with 2 and 4 g/day, respectively), exercise (reductions of 11.8% and 10.4% with 2 and 4 g/day, respectively), and recovery (reductions of 11.7% and 10.7% with 2 and 4 g/day, respectively). The observed magnitude of BP reduction suggests an association with ACE polymorphism; a larger effect was seen with the II and DI genotypes compared with the DD genotype (II: 121 mmHg and DI: 133 mmHg vs. DD: 144 mmHg). Conclusions. The results showed that L-arginine supplementation at low doses was efficient in reducing BP and that vasodilator actions that occurred through the secretion of nitric oxide might be ACE genotype dependent

human movement

Effects of L-Arginine Supplementation on Blood Pressure Reduction Pre-, Peri-, and Post-Cardiovascular Stimulus in Hypertensive Subjects with Different Angiotensin-Converting-Enzyme Genotypes