Open AccessStudy of Protective effect of Glutathione Peroxidase (GSH-Px), Vitamin E and Selenium on Iraqi children with Leukemia
Author(s) -
Saeed H. Assi,
Ryaidh Sh. Al_Husain
Publication year - 2014
Publication title -
maǧallaẗ markaz buḥūṯ al-taqniyyaẗ al-aḥyāʾiyyaẗ
Language(s) - English
Resource type - Journals
eISSN - 2708-1370
pISSN - 1815-1140
DOI - 10.24126/jobrc.2014.8.4.371
Subject(s) - glutathione peroxidase , leukemia , vitamin e , glutathione , chemistry , antioxidant , peroxidase , selenium , reactive oxygen species , acute myeloblastic leukemia , gpx4 , medicine , biochemistry , enzyme , immunology , organic chemistry
The present study have been investigated the levels of antioxidant substances which including the enzyme glutathione peroxidase GSH-Px, vitamin E (α- tocopherol), and selenium, in order to estimate their roles of preventing the body cells against oxidation processes by free radicals, hydrogen peroxides, hydrofattyperoxides, reactive oxygen species, which attack the cell membrane causing damage of these cells resulting in mutation of DNA and accidence of various cancer diseases such as leukemia. By studying 30 female and 30 male, 2-14 years old, they were divided into three groups, each group formed 20 patients. These groups included two kinds of leukemia are acute lymphoblastic leukemia (ALL) and acute myeloblastic leukemia (AML). The concentration level of glutathione peroxidase GSH-Px, and concentration level of α- tocopheroland selenium were significant P< 0.05 decrease in all groups of patients male and female in both kinds of leukemia's when compared to control group.