Open AccessTHE PECULIARITIES LOCAL IMMUNE REACTIONS IN ILEUM AT POSTRESECTION PORTAL HYPERTENSION
Author(s) -
Л. В. Татарчук,
M. S. Hnatyuk
Publication year - 2018
Publication title -
klìnìčna anatomìâ ta operativna hìrurgìâ
Language(s) - English
Resource type - Journals
eISSN - 1993-5897
pISSN - 1727-0847
DOI - 10.24061/1727-0847.17.2.2018.13
Subject(s) - ileum , portal hypertension , immune system , parenchyma , immunoglobulin e , antibody , medicine , chemistry , pathology , immunology , cirrhosis
In the experiment, in laboratory white male rats, local immune reactions were investigated in the ileum in conditions of postresection portal hypertension, which was modeled by removing 58.1% of liver parenchyma. It has been established that postresection portal hypertension leads to pronounced changes in local immune reactions in the ileum, characterized by a 29.6% reduction in secretory IgA, a plasmoncytes with IgA on 1 mm² on the mucosa by 32.5%, an uneven, disproportional increase in the number of plasmatic cells with IgM. IgG, IgE, respectively, by 77.0%, 4.1 and 5.1 times. The cell density of the infiltrate in the mucosa of the investigated organ increased by 37.0%, and the number of mast cells by 35.8%. The results obtained indicate that postresection portal hypertension leads to weakening, tension and instability of the local immune homeostasis of the ileum mucosa and marked structural changes in the wall of the investigated organ.